Molecular mechanisms of mutagenicity of DNA and other natural and synthetic polynucleotides
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Molecular mechanisms of mutagenicity of DNA and other natural and synthetic polynucleotides

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Published by National Academy of Science of Ukraine, Institute of Plant Physiology and Genetics in Kiev .
Written in English


  • Molecular genetics.,
  • Mutation (Biology),
  • Mutagenesis.

Book details:

Edition Notes

StatementS.M. Gershenson, Yu. N. Alexandrov.
ContributionsAlexandrov, Yu. N., Naëtìsional§na akademiëiìa nauk Ukraèiny.
The Physical Object
Pagination262p. ;
Number of Pages262
ID Numbers
Open LibraryOL17140343M

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Molecular models of induced DNA premutational damage and mutational pathways for the carcinogen 4-nitroquinoline 1-oxide and its metabolites. Chemico-Biological Interactions , 30 (1), Cited by: DNA is a polynucleotide, whose monomer units are composed of a monophosphorylated deoxyribose sugar linked to one of four nitrogenated nucleobases: two purines, called adenine (A) and guanine (G), and two pyrimidines, called thymine (T) and cytosine (C) []. DNA is the basic information storage molecule in nature. Clearly, a working hypothesis must be adopted and the one discussed here is widely accepted - namely, that the alkylating agents produce their cytotoxic, mutagenic, and carcinogenic effects by reacting with cellular DNA. Some data do not fit into this scheme easily, and other Cited by: Historically, helical DNA and RNA structures were first analyzed by fiber diffraction techniques, culminating in the double-helical model for DNA. Subsequent to , this approach has been applied to both natural duplex nucleic acids and to a wide range of synthetic polynucleotides.

Excimer fluorescence of dinucleotides, polynucleotides, and DNA Article (PDF Available) in Proceedings of the National Academy of Sciences 55(5) June with 24 Reads. However, chitosan/chitin by itself lacks good mechanical properties required in certain structural applications. Chemical modifications of chitosan and blending the polymer with other natural and synthetic polymers are done to overcome this limitation. On the whole, chitosan has a huge potential in tissue engineering and drug delivery by: The reaction of the carcinogen N-acetoxyacetylaminofluorene with DNA and other polynucleotides and its stereochemical implications. Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis , (3), DOI: /(71) Erik by: In double stranded DNA, the bases of one strand are paired with the bases in the other strand. Adenine (A) in one strand is paired with thymine (T) in the other strand and guanine (G) in one strand is paired with cytosine (C) in the other strand as well. In the DNA duplex structure, genetic information is stored as a linear nucleotide code.

The interaction of lac repressor with 21 base pair lac operator, chemically synthesized by a phosphotriester method, has been studied in considerable detail. The binding of the synthetic operator to the lac repressor is similar to that of natural operator in lambda plac DNA in its response to salt, temperature, and effector ligands. Mechanisms of Interaction of Polycyclic Aromatic Diol Epoxides with DNA and Structures of the Adducts NICHOLAS E. GEACINTOV Chapter 6, DOI: /bkch Publication Date (Print): J Srisvastava, B.I.S.: Inhibition of oncornavirus and cellular DNA polymerases by natural and synthetic polynucleotides. s. Acta , 77–85 () Google ScholarCited by: 5. Mutagenesis in the laboratory is an important technique whereby DNA mutations are deliberately engineered to produce mutant genes, proteins, or strains of organism. Various constituents of a gene, such as its control elements and its gene product, may be mutated so that the functioning of a gene or protein can be examined in detail.